Table 4.

Orotracheal intubation during an attack as a predictor of attack recovery

	Univariate odd ratio (IC 95%)	Multivariable odd ratio (IC 95%)
Age	1.1 (0.99;1.21)	1.11 (1;1.23)
Gender:woman	6.04 (0.46;79.72)
Attack occurring in the first 6 months of NMOSD-AQP4 disease	1.48 (0.49;4.44)
EDSS at admission	1.63 (1.11;2.38)	1.68 (0.92;3.46)
Previous DMT	0.39 (0.1;1.55)
Attack requiring orotracheal intubation	0.94 (0.11;8.28)	0.47 (0;3.22)
Attack treated with TPE	5.9 (1.21;28.83)	3.21 (0.45;56.2)

Unfavorable attack recovery = defined as modified Rankin score (mRS) > 2 at 12 months for patients with initial mRS ≤ 2 or an increase of ≥ 1 point in mRS for patients with initial mRS > 2

Variables included in the multivariable logistic regression were OTI and variables associated with unfavorable attack recovery in the univariate analysis. Odd ratios were estimated with binomial generalized linear mixed model, with a random intercept for patient ID

EDSS expanded disability severity score, DMT disease modifying therapy, TPE therapeutic plasma exchange