Table 2.
Distribution of genotypic and allelic frequencies of five PD-1 and three PD-L1 gene variants in 125 patients with advanced melanoma
| Single nucleotide variant | Genotype | Patients (n = 125) |
Allele | Alleles (2n = 250) |
||
|---|---|---|---|---|---|---|
| No. | % | No. | % | |||
| PD1.3 G>A (rs11568821) | G/G | 92 | 73.6 | G | 216 | 86.4 |
| G/A | 62 | 25.6 | A | 34 | 13.6 | |
| A/A | 1 | 10.4 | ||||
| (P value) | (0.318) | |||||
| PD1.5 C>T (rs2227981) | C/C | 51 | 40.8 | C | 163 | 65.2 |
| C/T | 61 | 48.8 | T | 87 | 34.8 | |
| T/T | 13 | 10.4 | ||||
| (P value) | (0.399) | |||||
| PD1.6 G>A (rs10204525) | G/G | 109 | 87.2 | G | 234 | 93.6 |
| G/A | 16 | 12.8 | A | 16 | 6.4 | |
| A/A | 0 | 0.0 | ||||
| (P value) | (0.444) | |||||
| PD1.7 T>C (rs7421861) | T/T | 59 | 47.2 | T | 166 | 66.4 |
| T/C | 48 | 38.4 | C | 84 | 33.6 | |
| C/C | 18 | 14.4 | ||||
| (P value) | (0.119) | |||||
| PD1.10 C>G (rs5582977) | C/C | 117 | 93.6 | C | 242 | 96.8 |
| C/G | 8 | 6.4 | G | 8 | 3.2 | |
| G/G | 0 | 0.0 | ||||
| (P value) | (0.712) | |||||
| PD-L1 +8293 C>A (rs2890658) | C/C | 87 | 69.6 | C | 210 | 84.0 |
| C/T | 36 | 28.8 | A | 40 | 16.0 | |
| T/T | 2 | 1.6 | ||||
| (P value) | (0.416) | |||||
| PD-L1 C>T (rs2297136) | C/C | 13 | 10.4 | C | 91 | 36.4 |
| C/T | 65 | 52.0 | T | 159 | 63.6 | |
| T/T | 47 | 37.6 | ||||
| (P value) | (0.169) | |||||
| PD-L1 G>C (rs4143815) | G/G | 62 | 49.6 | G | 176 | 70.4 |
| G/C | 52 | 41.6 | C | 74 | 29.6 | |
| C/C | 11 | 8.8 | ||||
| (P value) | (0.944) | |||||
P value: probability level associated with the chi-square test for departures from the Hardy–Weinberg equilibrium.
PD-L1, programmed death-ligand 1.