Table 2.

TB states conceptual definitions and terminology.

State	Conceptual theme	Terminology used to describe state	Articles describing state (n)	%
State 0	Infection has been eliminated with innate immune response	Uninfected, Innate immune Response, Innate immune elimination, No Disease (TB Negative), Eliminated TB infection, Infection controlled/eliminated/Stable, Uninfected individual, No M. tuberculosis infection, Cleared, Latent Clearance, Uninfected, Initial infection, TB infection, Innate Immune Cell Recruitment, Colonization and Early Clearance, Infection, Resistance to Infection, Stage 1, Elimination of infection (self-resolving infection), Infection eliminated (with innate immune)	25	63%
State I	Infection has been eliminated by acquired immune response	Acquired Immune, Adaptive Immune Response, LTBI, No Disease (Latent TB), Acquired Immune Response, Acquired Immune Elimination—memory, LTBI—Asymptomatic, Eliminated TB infection, Acquired Immune, Infection controlled/Eliminated/Stable, Non-progression or Self-cure from Subclinical Stage, Primary or secondary M. tuberculosis infection, LTBI—Reverter, Latent Clearance, Reduced Reactivation Risk, Adaptive Immune Phase, Transient Infection, Adaptive Immune Cell Activation, Resister, Clearance of Infection, Mtb infection, Latent TB infection, AsymptomaticLTBI—Incident	31	78%
State II	Infection is not eliminated but is controlled by the immune system	Quiescent Infection, Latent Mtb infection, LTBI, Incipient TB, Latent Infection, No Disease (Latent TB), Quiescent, Unstable LTBI, Latent Non-infectious tuberculosis, Mtb infection, Immunological equilibrium (latency), Latent Subclinical or Low Grade TB, Primary Infection, Latent Infection Dormant/Persistent, Traditional LTBI, Incipient TB, Caseating granuloma, Persistent TB, Containment of infection (Established Latency)	37	93%
State III	Infection is not controlled by the immune system	Incipient, Incipient TB infection, Incipient TB disease, No Disease (Latent TB), Active Infection, Subclinical TB Disease, Asymptomatic, Incipient disease, Unstable LTBI Incipient, Infectious Tuberculosis, Active Severe TB, Resuscitation, Reactivation TB, Percolating Infection, Progressor/Incipient TB, Stage 2, Failure to Contain Infection (subclinical active TB), Culture-Negative TB	24	60%
State IV	Individual is bacteriologically positive but has no symptoms or clinical features	Subclinical, Subclinical TB Disease, Asymptomatic, Bacteriologically Positive, Subclinical Active Phase, Subclinical No Symptoms, Additional Infectious Tuberculosis, Subclinical TB with no Signs/Symptoms, Subclinical Disease, Subclinical/Incipient, Active Infection, Incipient TB, Asymptomatic Pre-clinical, Stage 3, Failure to contain infection (Primary Active TB), Subclinical Infection, Quiescent	26	65%
State V	Individual has signs or symptoms associated with TB	Active TB Disease, Clinical TB, Disease (Active TB), Disease, Minimal, Active TB DiseaseSymptomatic Clinical Bacteriologically Negative, Pre-diagnostic TB Disease, Clinical TB, Subclinical Symptoms not Recognized, Clinical Disease (Symptoms) Infectious Period, Active Clinical TB Disease, Chronic TB, Reactivation/Secondary TB, Reactivation, TB Disease, Transmission, Active TB, Smear Negative, Active TB Caseating Granuloma, At Risk for TB, Primary Active Disease, Active TB, Symptomatic—Clinical, Stage 4, Breakdown of Immune Control (Active TB), Definite TB	39	98%
State VI	High severity of disease due to clinical features, radiology or bacteriology	Cavitary/Disseminated, Active TB DiseaseSymptomatic Clinical Smear Positive/Extensive Disease, Dissemination disease, Active, Severe, Symptomatic Culture PositiveSmear Positive,	11	28%
State VII	Previous History of TB	Asymptomatic Past TB, No Disease (Past TB), Treated/Recovered, Treated, Old Disease, Relapse, Reinfection	5	13%

Footnote: Three most frequently used terms for each state are highlighted in bold.

Abbreviated terms have been included as described in the article text, tables or diagrams.

Tuberculosis (TB), Mycobacterium tuberculosis (Mtb), Latent Tuberculosis Infection (LTBI).