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I-SPY 2 Trial design, RPPA workflow, and patient distribution
(A) I-SPY 2 Trial schematic.6
(B) Patient number distribution by trial arm and HR/HER2 status in the reverse phase protein array (RPPA) dataset. Ctr, control; N, neratinib; PD1-inh, PD1 inhibitor; TDM1/P, TDM1 + pertuzumab; VC, veliparib + carboplatin.
(C) RPPA workflow (image modified from Loebke et al.9).
