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. 2023 Dec 11;4(12):101312. doi: 10.1016/j.xcrm.2023.101312

Figure 2.

Figure 2

Association of protein/phosphoprotein expression with pCR by arm

(A) Dot plot of protein/phosphoprotein analytes (columns) having significant associations with pCR in one or more treatment arm(s) of the I-SPY 2 Trial or across 8 arms (rows); X, data not available.

(B) Boxplots of TYK2 Y1054/Y1055 and STAT1 Y701 (top) with JAK2 Y1007 and STAT5 Y694 (bottom) expression by pCR status across all arms. Green, no pCR; orange, pCR.

(C) Boxplots of AR S650 (top) and ER total (bottom) by pCR status in the PD1-inh arm. Blue, no-pCR; pink, pCR.

(D) Boxplot of cyclin D1 expression within each arm by pCR status. Blue, non-pCR; pink, pCR. Unadjusted p values annotated within each graph; n.s., not significant; Boxes show median and 25th to 75th interquartile range (IQR). Whiskers denote largest/smallest values within 1.5× the IQR.