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. 2023 Dec 11;4(12):101312. doi: 10.1016/j.xcrm.2023.101312

Figure 3.

Figure 3

Protein signaling pathway activation-based characterization of receptor subtypes

(A) One-way clustering of analytes with a significant expression difference in at least one subtype pair. Mean intensity values for each endpoint within each subtype were calculated and used for clustering. Mean values from blue to red represent low to high. Bar graph: pCR rate (%) for each subtype across all arms in the study. Blue arrows, PD1/PDL1; green arrow, STAT3 S727; and red arrows, STAT5 Y694 and TYK2 Y1054/Y1055 expression levels.

(B) Association dot plot of protein/phosphoprotein analytes (rows) having significant association with pCR in one or more HR/HER2 subtypes and/or across all subtypes.

(C) Boxplots for total ERα (left), AR S650 (center), and cyclin D1 total (right) in all patients (upper) and the HR+HER2− subset (lower) demonstrating associations with non-pCR. Blue, no pCR; pink, pCR. Boxes show median and 25th to 75th IQR. Whiskers denote largest/smallest values within 1.5× the IQR.