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. 2023 Dec 19;4(12):101333. doi: 10.1016/j.xcrm.2023.101333

Figure 3.

Figure 3

T cells of SAVI have impaired signature score of trafficking machinery, and naive cells have increased activation markers and senescence signature score

(A) Heatmap of the pathway enrichment analysis between SAVI and CTRL. Dots indicate non-significant pathways (Bonferroni-Hochberg corrected p values > 0.05). Side color bar indicate groups of pathways based on broader functions.

(B and C) Heatmaps of a lymphocyte trafficking signature in T cells of (B) the SAVI dataset and (C) the IFN-β dataset.

(D and E) Feature plots of CD69 mRNA expression level in T cells in (D) the SAVI dataset and (E) the IFN-β dataset. nCD4, naive CD4; eCD4, effector CD4; nCD8, naive CD8; eCD8, effector CD8.

(F and G) T cell activation signature score in T cells of (F) the SAVI dataset and (G) the IFN-β dataset over the time course of IFN-β stimulation.

(H and I) Senescence signature score in T cells of (H) the SAVI dataset and (I) the IFN-β dataset over the time course of IFN-β stimulation.

(J and K) Apoptosis signature score in (J) the SAVI dataset and (K) the IFN-β dataset over the time course of IFN-β stimulation. (J and F) Dark lines indicate medians. (G–I and K) Each dot is the average score of the signature for a sample.