Skip to main content
. 2023 Dec 19;4(12):101333. doi: 10.1016/j.xcrm.2023.101333

Figure 4.

Figure 4

SAVI patients present a disease-associated cluster of monocytes characterized by elevated type I IFN response, NF-κB activation, and ISR

(A) UMAP of the monocytes and DCs in the SAVI dataset, separated by groups. Black circle indicates cluster 17 (disease-associated monocytes).

(B) Composition of monocyte and DC clusters in the SAVI dataset.

(C) Violin plots of the signature score of type I IFN response (top) and of NF-κB activation (bottom) in the SAVI dataset.

(D) Dot plot of the expression levels of all type I and type III IFNs, in each monocyte and DC clusters, in the SAVI group.

(E) Volcano plot of the differentially expressed gene (DEGs) between the cells from SAVI patients in cluster 17 (disease-associated monocytes) and cluster 5 (classical monocytes).

(F) Pathway enrichment analysis between cells from SAVI patients in cluster 17 (disease-associated monocytes) and cluster 5 (classical monocytes). Side color bar indicate groups of pathways based on broader functions.

(G) Violin plot of the expression of PPP1R15A which codes for GADD34 (top) and a UPR signature of 85 genes (bottom) in the SAVI dataset. (C and G) Dark lines indicate medians.