Isotope tracing reveals the dose- and time-dependent metabolic fate of ingested-protein-derived amino acids
(A–C) Cumulative amount of ingested protein that is released into the circulation (A), incorporated into plasma protein (B), and incorporated into skeletal muscle (C).
(D) Metabolic fate of ingested protein expressed in absolute and relative amounts.
(E) Plasma protein synthesis rates based on L-[1-13C]-leucine and the plasma precursor pool.
(F–H) Contribution of endogenous and exogenous rates to the total rate of appearance (F), rate of disappearance (G), and muscle protein synthesis rate (H).
All values are means ± SD. For all measurements, n = 12 biological replicates.