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. 2023 Nov 17;5(1):21–33. doi: 10.1158/2643-3230.BCD-23-0112

Figure 3.

Figure 3. Association of serum analytes with high grade (≥3) toxicity or efficacy. A, A panel of 29 inflammatory and immune-modulatory markers were analyzed in serum with validated Meso Scale Discovery methods (Medpace). Associations of serum analytes with Grade ≥3 CRS and NEs are reported. Serum analytes shown were elevated in ≥50% of patients with ≥2-fold induction (peak, defined as the maximum cytokine serum level after baseline) above baseline (the time point prior to optional bridging and lymphodepleting chemotherapy). Dark blue indicates analytes that associated with CRS and/or NEs similarly in ZUMA-1 (3–5, 47) and ZUMA-7. B, Association of cytokines with CRS. C, Association of cytokines with NEs. D, Association between DOR, EFS, and PFS, and postinfusion cytokines. E, Association between CR, ongoing response, and ORR, and postinfusion cytokines. For B, C, and E statistical differences were analyzed using logistic regression test. For D, statistical differences were analyzed using Cox regression test. * No associations with grade ≥3 CRS or grade ≥3 NE in ZUMA-1. † Not tested in ZUMA-1. CR, complete response; NE, neurologic event; CRP, C-reactive protein.

Association of serum analytes with high grade (≥3) toxicity or efficacy. A, A panel of 29 inflammatory and immune-modulatory markers were analyzed in serum with validated Meso Scale Discovery methods (Medpace). Associations of serum analytes with Grade ≥3 CRS and NEs are reported. Serum analytes shown were elevated in ≥50% of patients with ≥2-fold induction (peak, defined as the maximum cytokine serum level after baseline) above baseline (the time point prior to optional bridging and lymphodepleting chemotherapy). Dark blue indicates analytes that associated with CRS and/or NEs similarly in ZUMA-1 (3–5, 47) and ZUMA-7. B, Association of cytokines with CRS. C, Association of cytokines with NEs. D, Association between DOR, EFS, and PFS, and postinfusion cytokines. E, Association between CR, ongoing response, and ORR, and postinfusion cytokines. For B, C, and E statistical differences were analyzed using logistic regression test. For D, statistical differences were analyzed using Cox regression test. * No associations with grade ≥3 CRS or grade ≥3 NE in ZUMA-1. † Not tested in ZUMA-1. CR, complete response; NE, neurologic event; CRP, C-reactive protein.