Table 2.

Features of MRD marker mutations in acute myeloid leukemia.

Feature	DTA a	NPM1	FLT3-ITD
Clonal hierarchy	Preleukemic	Leukemia-initiating	Usually subclone
High frequency	Yes	Yes	Yes
AML specificity	No	Yes	No
Distinct GEP	No	Yes	No
Clonal hematopoiesis	Yes	No	No
Clearance post-morphologic CR	No	Yes	Yes
Prediction of relapse	No	Yes	No
Stability at relapse	Yes	Yes	No
Sample source	gDNA	Usually cDNA	gDNA

Abbreviations: GEP, gene-expression profile; CR, complete remission; gDNA, genomic DNA.

^a DTA: DNMT3A, TET2, ASLX1 mutations.