Figure 2.

The three ROC curves produced by PSI-BLAST, HI^all, and HI^seq for predictions in the twilight zone. While the ROC curve for PSI-BLAST results from applying ROC analysis directly to the results produced, the ROC curves for both HI methods are maximized using an optimal value for re-sorting. The ROC curve for HI^all dominates over the other two curves at all times; while the curves for PSI-BLAST and HI^seq oscillate around each other. HI^seq dominates the PSI-BLAST curve between ~0.38 and ~0.5.