Table 1.
Comparisons of the average probabilities of longevity between males and females with various standardized PRS summarizing each of the eight groups of sex-specific genes jointly associated with longevity at different significance levels.
| Average probability of longevity |
Ave. prob. of longevity in females higher than in males |
P value of sex difference |
|||
|---|---|---|---|---|---|
| Females | Males | Diff. | % of diff. | ||
| A. Analyses based on the CLHLS GWAS datasets | |||||
| (I) Sex-specific top genes jointly associated with longevity | |||||
| (1) 11 male-specific top genes jointly associated with longevity (each of them has P < 10−5 in males, but P > 0.16 in females) | 0.513 | 0.420 | 0.093 | 22.15 % | 8.4 × 10−09 |
| (2) 11 female-specific top genes jointly associated with longevity (each of them has P < 10−5 in females, but P > 0.12 in males) | 0.514 | 0.423 | 0.090 | 21.34 % | 3.8 × 10−08 |
| (II) Sex-specific strong genes jointly associated with longevity | |||||
| (3) 35 male-specific strong genes jointly associated with longevity (each of them has 10−5≤P < 10−4 in males, but P > 0.25 in females) | 0.513 | 0.420 | 0.093 | 22.10 % | 1.9 × 10−08 |
| (4) 25 female-specific strong genes jointly associated with longevity (each of them has 10−5≤P < 10−4 in females, but P > 0.36 in males) | 0.516 | 0.423 | 0.093 | 22.06 % | 7.8 × 10−09 |
| (III) Sex-specific moderate genes jointly associated with longevity | |||||
| (5) 191 male-specific moderate genes jointly associated with longevity (each of them has 10−4≤P < 10−3 in males, but P > 0.75 in females) | 0.514 | 0.415 | 0.099 | 23.95 % | 2.0 × 10−09 |
| (6) 311 female-specific moderate genes jointly associated with longevity (each of them has 10−4≤P < 10−3 in females, but P > 0.70 in males) | 0.515 | 0.422 | 0.093 | 21.93 % | 1.5 × 10−08 |
| B. Analyses based on the CLHLS healthy aging candidate genes datasets | |||||
| (IV) Sex-specific genes jointly associated with longevity | |||||
| (7) 30 Male-specific jointly associated with longevity (each of them has P < 0.05 in males, but P > 0.10 in females) | 0.701 | 0.570 | 0.130 | 22.88 % | 3.0 × 10−47 |
| (8) 74 female-specific genes jointly associated with longevity (each of them has P < 0.05 in females, but P > 0.10 in males) | 0.689 | 0.540 | 0.149 | 27.53 % | 1.1 × 10−45 |