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. 2023 Dec 21;12(12):1871–1884. doi: 10.21037/tau-23-573

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2023 Translational Andrology and Urology. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Effect of Klotho on renal function, inflammatory factors, oxidative stress and pathological kidney injury. (A,B) Levels of Scr (A) and BUN (B) in serum. n=6. (C,D) Levels of NGAL (C) and Kim-1 (D) in serum. n=6. (E,F) Levels of TNF-α (E) and IL-6 (F) in serum. n=6. (G-I) Levels of GSH-Px (G), T-SOD (H) and MDA (I) in serum. n=6. The results are expressed as the means ± standard deviation. *, P<0.05; **, P<0.01. CLP, cecal ligation and puncture; Lip-1, liprostatin-1; Klotho, recombinant human Klotho protein; Scr, serum creatinine; BUN, blood urea nitrogen; NGAL, neutrophil gelatinase-associated lipocalin; Kim-1, kidney injury molecule 1; TNF-α, tumor necrosis factor-α; IL-6, interleukin-6; GSH-Px, glutathione peroxidase; SOD, superoxide dismutase; MDA, malondialdehyde.