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Disposition of trial participants. aTwo participants excluded due to error in sample processing. bTwo participants withdrew for personal reasons without any related safety/tolerability concerns. c Two participants prematurely withdrew before day 14. BID, twice daily; CSF, cerebrospinal fluid; ECG, electrocardiogram; n/a, not applicable; MAD, multiple ascending dose; QD, once daily; PD, pharmacodynamic; PK, pharmacokinetic; SAD, single ascending dose.
