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. 2023 Dec 1;300(1):105524. doi: 10.1016/j.jbc.2023.105524

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© 2023 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Piezo1 expression in the kidney is most abundant in the collecting duct. Representative confocal micrographs showing Piezo1 (pseudocolor green), AQP2 (pseudocolor red) reporting signals, and the merged image in renal cortical (top row) and medullary (bottom row) sections. Nuclear DAPI staining is shown with pseudocolor blue. Piezo1-reporting signal predominantly localizes to the AQP2-positive (collecting duct) segments of the renal nephron. At the same time, a weaker basolateral Piezo1 signal is present in AQP2-negative renal tubules. AQP2, aquaporine 2; DAPI, 4′,6-diamidino-2-phenylindole.