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Principal scheme of Piezo1 function and regulation in principal (PCs) and intercalated (ICs) cells in the collecting duct. TRPV4–transient receptor potential vanilloid channel type 4. The size of respective icons of Piezo1 and TRPV4 reflects their activity. Green and red arrows represent stimulatory and inhibitory actions, respectively. TRPV4, transitransient receptor potential vanilloid channel type 4.
