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. 2023 Dec 7;79:101850. doi: 10.1016/j.molmet.2023.101850

Figure 6.

Figure 6

Potential effect of NN1177 on the transcriptome in human NASH.A. Genes significantly associated with fibrosis score and NAFLD activity scores in human livers are grouped by direction of effect of NN1177 in mice. Opposite: NN1177 has an opposite effect in mice than fibrosis/NAFLD in human livers (for opposite genes, upregulated = upregulated in mice data, downregulated in human data, and inversely). Same: NNC117 has a similar effect in mice than fibrosis/NAFLD in human livers. B. Over-representation enrichment analyses (KEGG pathways) genes significantly associated with NASH in human and/or NN1177 in mice (ordinal regression analysis NASH vehicle < NN1177 low < NN1177 med < NN1177 high). The pathways represented are selected from the top 5 pathways per gene-sets. Each gene-set tested is identified by a number in bracket and referenced with this number in the results. The numbers of genes in each gene sets are shown in parenthesis. The following gene-sets tested had no significant enrichments and are not represented in the plot: “Decreased in Human Fibrosis” (n = 124), “Opposite direction in human NAS” (n = 435), “Same direction Human NAS” (n = 166), “Same direction Human Fibrosis” (n = 47). Full differential expression and enrichment results are presented in Suppl. Table 3.