Table 3.

Inhibitor and anti–factor IX immunoglobulin G1 titers in hemophilia B mice that received 0.01 to 1 IU of FIX-Fc intradermally + intraperitoneally/intravenously.

Animal group	1 IU FIX IP/i.v.	0.01 IU FIX-Fc ID + IP/i.v.	0.1 IU FIX-Fc ID + IP/i.v.	1 IU FIX-Fc ID + IP/i.v.
Inhibitor (BU/mL), mean ± SD	0.8 ± 0.7	0.8 ± 1.1	8.4 ± 8.7	41.9 ± 28.1
IgG1 (μg/mL), mean ± SD	72.9 ± 100.8	144.5 ± 115.5	351.4 ± 177.0	516.3 ± 311.7

BU, Bethesda unit; FIX, factor IX; ID, intradermally; IP, intraperitoneal; i.v., intravenous.