Fig. 1.
Distribution of immunoassay and mass spectrometry p-tau181, p-tau217 and p-tau231 concentrations by clinical diagnosis. Density plots represent the proportion of subjects (y-axis) at different concentrations of p-tau (x-axis) for mass spectrometry-based quantification of p-tau (top row & 3rd row) and immunoassay-based quantification of p-tau (2.nd row & bottom row). P-tau217 showed high specificity for AD with lower values for young adults and CU older adults. CUY = Cognitively unimpaired young adults; CU = Cognitively unimpaired older adults; MCI = Mild cognitive impairment; AD = Alzheimer’s disease; OND = Other neurodegenerative disease. *: p < 0.05; ** p < 0.01; *** p < 0.005; **** p < 0.001