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. 2023 Dec 18;27(2):62. doi: 10.3892/ol.2023.14193

Table III.

Uni- and multivariate analyses for CS-AZA1 and CLFS-AZA1.

CS-AZA1 CLFS-AZA1
Univariate analysis Multivariate analysis Univariate analysis Multivariate analysis
Factors Variables HR 95% CI P-value HR 95% CI P-value HR 95% CI P-value HR 95% CI P-value
Age <75 Reference Reference
≥75 1.10 0.76–1.62 0.609 1.26 0.87–1.83 0.214
Sex Female Reference Reference Reference
Male 1.42 0.94–2.13 0.095 1.45 0.98–2.29 0.062 1.26 0.85–1.86 0.255
Cytogenetic Very good, good, Reference Reference Reference Reference
risk according intermediate,
to IPSS-R and poor
classification Very poor 2.12 1.44–3.13 <0.001 2.18 1.42–3.33 <0.001 1.80 1.24–2.61 0.002 1.80 1.20–2.71 0.004
Blast in bone <10% Reference Reference
marrow ≥10% 0.94 0.63–1.41 0.782 1.06 0.72–1.56 0.764
Hemoglobin ≥8 g/dl Reference Reference Reference Reference
level <8 g/dl 1.42 0.97–2.08 0.070 1.33 0.88–1.99 0.175 1.49 1.03–2.15 0.034 1.39 0.94–2.06 0.098
Platelet counts ≥50×109/l Reference Reference Reference Reference
<50×109/l 1.60 1.08–2.36 0.018 0.73 0.44–1.22 0.227 1.47 1.01–2.15 0.047 0.89 0.56–1.43 0.639
ANC ≥0.8×109/l Reference Reference Reference Reference
<0.8×109/l 1.55 1.05–2.29 0.028 1.40 0.89–2.22 0.146 1,40 0.95–2.05 0.088 1.23 0.78–1.91 0.372
RCC28 ≤6 units Reference Reference Reference Reference
>6 units 2.98 1.89–4.70 <0.001 1.57 0.90–2.73 0.114 2.60 1.66–4.09 <0.001 1.50 0.87–2.61 0.148
PC28 ≤30 units/month Reference Reference Reference Reference
>30 units/month 2.74 1.68–4.47 <0.001 2.90 1.56–5.37 <0.001 2.36 1.45–3.83 0.001 2.05 1.13–3.73 0.018
ANC29 ≥0.18×109/l Reference Reference Reference Reference
<0.18×109/l 1.71 1.11–2.64 0.016 1.09 0.65–1.83 0.739 1.58 1.04–2.46 0.032 1.13 0.68–1.87 0.643

ANC, absolute neutrophil counts; AZA, azacitidine; CS-AZA1, conditional survival period after the first cycle of AZA treatment; CLFS-AZA1, conditional leukemia-free survival period after the first cycle of AZA treatment; IPSS-R, revised international prognostic scoring system; RCC28, Unit of red cell concentrates transfused within the first 28 days of AZA treatment; PC28, Unit of platelet concentrate transfused within the first 28 days of AZA treatment; ANC29, absolute neutrophil counts on day 29 after the start of AZA treatment.