Figure 2.

In vitro efficacy of CMV-TCR-T cells. (A–C) Transduction rate of CMV-specific TCRs with different HLA restrictions was represented by the percentage of tetramer⁺ population. Non-transduced T cells corresponding to each group of TCR-T cells were used as negative controls (NC). (D–F) In vitro cytolytic activity against HLA-matched/unmatched target cells of CMV-TCR-T cells with different HLA restrictions, compared with corresponding NC. Asterisks indicated statistical significance determined by paired Student’s t-tests between groups (*p<0.05). CMV, cytomegalovirus; HLA, human leukocyte antigen; N.S., not significant; TCRs, T cell receptors; SSC, side scatter; SSC-H, side scatter height; PE-H, phycoerythrin height.