Table 3.
Proposed factor combination by MODDE and relative responses obtained (n = 3).
| Factors | Responses | ||||
|---|---|---|---|---|---|
| Run | Decanoic acid (g) | Miglyol 812® N (g) | Temperature (±°C) | Dissolution time (min) | Precipitation time (months) at 21–23 °C |
| 1 | 1.0 | 2.0 | 35 | 36 ± 2.0 | 12 |
| 2 | 1.0 | 1.0 | 60 | 13 ± 1.0 | 12 |
| 3a | 0.55 | 1.5 | 47.5 | 25 ± 1.5 | 12 |
| 4a | 0.55 | 1.5 | 47.5 | 23.7 ± 1.5 | 12 |
| 5 | 0.1 | 2.0 | 60 | 39 ± 1.5 | 1.75 |
| 6 | 0.1 | 1.0 | 60 | 49.5 ± 2.1 | 0.5 |
| 7a | 0.55 | 1.5 | 47.5 | 26 ± 2.0 | 12 |
| 8a | 0.55 | 1.5 | 47.5 | 21 ± 4.0 | 12 |
| 9b | 0.1 | 1.0 | 35 | 92 | 0 |
| 10a | 0.55 | 1.5 | 47.5 | 19 ± 3.2 | 12 |
| 11 | 1.0 | 1.0 | 35 | 28.7 ± 2.9 | 12 |
| 12 | 1.0 | 2.0 | 60 | 16 ± 3.1 | 12 |
| 13b | 0.1 | 2.0 | 35 | 97 | 0 |
a
Center points.
b
Lumefantrine did not dissolve within the specified period.