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. 2023 Dec 20;14:1327875. doi: 10.3389/fimmu.2023.1327875

Figure 3.

Figure 3

T-cell response to Spike from Original Vaccine Strain is induced in both naive and previously infected children, as shown by IFN-γ ELISpot. IFN-γ-producing cells among PBMC cultured in the presence of overlapping peptides of the Spike antigen from SARS-CoV-2 Original Strain, expressed as spot forming units (SFU) corrected for DMSO controls. SFU before vaccination and after vaccination in children without SARS-CoV-2 infection prior to vaccination (A) or in children with SARS-CoV-2 infection prior to vaccination (B). Individual SFU (dots) and their median values in PBMC from children infected prior to their vaccination (‘Infected’), from uninfected children after their vaccination, or from previously infected children after their vaccination (C). Statistical significance of differences was analyzed by Wilcoxon test (A, B) and Kruskall-Wallis test with Dunn’s correction for multiple testing (C). * = p < 0.05, ** = p < 0.01, *** = p < 0.001.