Table:
Microbial signatures related to gastrointestinal cancer risk and prognosis
| Tissue | Cancer-associated bacteria | |
|---|---|---|
| Oesophagus | Cancerous tissue | Species: Fusobacterium nucleatum,69 Porphyromonas gingivalis73 |
| Stomach | Cancerous tissue | Phylum: Actinobacteria,50
Firmicutes,50
Proteobacteria50 Family: Enterobacteriaceae,50 Pasteurellaceae,51 Xanthomonadaceae,50 Streptococcaceae76 Genus: Achromobacter,50 Bacillus,51 Bifidobacterium,51 Citrobacter,50 Clostridium,50 Fusobacteria,51 Lactococcus,50,51 Leptotrichia,51 Methylobacterium,51 Phyllobacterium,50 Rodococcus,50 Staphylococcus,51 Veillonella 51 Species: Dialister pneumosintes,49,51 Helicobacter pylori,76 Parvimonas micra,49 Peptostreptococcus stomatis,49 Slackia exigua,49 Streptococcus anginosus49 |
| Colon and rectum | Cancerous tissue | Genus: Fusobacterium,6,18
Gemella,6
Granulicatella,6
Parvimonas,6
Peptostreptococcus6 Species: Bacteroides fragilis,6 Escherichia coli,5 F nucleatum2,3,6,19 |
| Colon and rectum | Faeces | Family: Enterococcaceae,23,24
Lachnospiraceae,24,73
Veillonellaceae22 Genus: Alistipes,23,73 Anaerococcus,2 Atopobium,22 Bacteroides,23,24,73 Blautia,23 Campylobacter,23 Clostridium,25 Dorea,23 Escherichia,23 Eubacterium,23 Fastidiosipila,23 Fusobacterium,22–24 Gemella,23 Holdermania,23 Leptotrichia,23 Odoribacter,23,73 Parabacteroides,23,73 Parvimonas,23 Peptostreptococcus,23,25 Phascolarctobacterium,23,24 Porphyromonas,22,24 Pseudomonas, Ruminococcus,23,25 Subdoligranulum23 Species: Alistipes putredinis,73 B fragilis,25 Bilophila wadsworthia,73 E coli,73 Eubacterium spp,25 Clostridium symbiosum,25,73 F nucleatum,25 P stomatis,25 Porphyromonas asaccharolytica,25 Streptococcus salivarius25 |
| Pancreas | Cancerous tissue | Class: Bacteroidea,71
Clostridia,71
Spingobacteriia53 Order: Corynebacteriales,71 Pseudomonadales71 |
| Gallbladder | Bile | Species: Enterobacter spp,56 E coli,56 F nucleatum,56 Salmonella enterica serotype Typhi54 |
| Bile duct | Cancerous tissue | Species: Helicobacter spp55 |
Data are from research studies mentioned in this Review. Only data from patient samples are included (microbial composition from mouse studies were excluded). Not all studies found the same microbial signatures, and they differed in their level of taxonomic resolution.