图 2.

fAβ_25-35、SFN和p38抑制剂SB203580对BV-2细胞M1/M2极化的影响

Effects of 50 μmol/L fAβ_25-35, 10 μmol/L SFN and 20 μmol/L SB203580 on M1/M2 polarization in BV-2 cells. A, B: Expression levels of TNF-α and IL-6 mRNA in BV-2 cells treated with vehicle, fAβ_25-35, fAβ_25-35+SFN, and fAβ_25-35+SB203580 for 24 h. C, D: Supernatant TNF-α and IL-6 concentration in BV-2 cell cultures treated with vehicle, fAβ_25-35, fAβ_25-35 +SFN, and fAβ_25-35 + SB203580 for 24 h. E: Expression levels of CD16/32 and CD206 in BV-2 cells with different treatments analyzed by flow cytometry. F, G: Quantification of CD16/32 and CD206 expressions. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001, ^****P < 0.0001.