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. 2023 Dec 30;35(6):675–685. doi: 10.21147/j.issn.1000-9604.2023.06.11

Table S2. Estimated costs of each stage of cervical lesions throughout disease courses (Inline graphic).

Stages Courses of disease Median total costs (IQR) Weight (%) Reference Estimated total costs (IQR)
IQR, interquartile range; LSIL, low-grade squamous intraepithelial lesion; HSIL, high-grade squamous intraepithelial lesion.
Rural          
 LSIL Diagnosis 48.3 (21.4−127.1) 100 Assumed 459.0 (167.7−1,330.3)
Initial treatment 171.4 (56.6−555.8) 100 Assumed
Follow-up 246.7 (92.4−667.5) 97.0 Assumed
 HSIL Diagnosis 88.2 (77.1−215.3) 100 Assumed 1,230.5 (560.6−2,104.5)
Initial treatment 717.1 (374.3−1,097.8) 100 Assumed
Follow-up 408.3 (98.5−763.1) 97.0 Assumed
Recurrence/progress 1,814.6 (847.0−3,201.3) 1.6 (18)
Urban          
 LSIL Diagnosis 285.7 (170.1−481.5) 100 Assumed 1,637.7 (956.4−2,669.2)
Initial treatment 684.4 (379.1−1,067.5) 100 Assumed
Follow-up 688.2 (419.7−1,154.9) 97.0 Assumed
 HSIL Diagnosis 293.6 (172.1−497.1) 100 Assumed 2,467.1 (1,579.1−3,762.3)
Initial treatment 1,250.7 (862.7−1,698.2) 100 Assumed
Follow-up 921.4 (547.1−1,562.7) 97.0 Assumed
Recurrence/progress 1,814.6 (847.0−3,201.3) 1.6 (18)
National          
 IA Diagnosis 354.6 (170.9−749.8) 100 (19) 15,034.9 (11,083.4−21,632.4)
Initial treatment 3,863.1 (3,229.9−5,490.8) 100 (19)
Chemoradiotherapy 14,313.8 (10,535.9−19,690.5) 63.5 (19)
Follow-up 1,657.7 (927.4−2,837.8) 97.0 (20)
Recurrence/metastasis 4,288.0 (3,313.4−4,840.4) 2.8 (21)
 IB Diagnosis 371.4 (179.3−815.1) 100 (19) 19,438.6 (14,060.0−26,505.9)
Initial treatment 6,554.2 (5,243.3−8,002.1) 100 (19)
Chemoradiotherapy 12,739.1 (10,214.8−16,915.1) 63.5 (19)
Follow-up 3,418.4 (1,621.5−6,186.1) 97.0 (20)
Recurrence/metastasis 10,861.5 (5,668.7−9,284.8) 10.2 (21)
 IIA Diagnosis 328.6 (185.7−580.0) 100 (19) 22,968.8 (16,068.8−34,615.9)
Initial treatment 6,605.8 (4,974.9−9,751.4) 100 (19)
Chemoradiotherapy 14,701.9 (10,333.8−19,216.9) 79.6 (19)
Follow-up 2,448.4 (1,256.7−5,360.0) 97.0 (20)
Recurrence/metastasis 11,787.7 (8,816.4−22,823.8) 16.6 (21)
 IIB Diagnosis 487.9 (213.3−1,449.6) 100 (19) 26,936.0 (18,176.6−41,386.0)
Initial treatment 7,481.9 (5,023.7−11,424.8) 100 (19)
Chemoradiotherapy 13,698.6 (10,579.8−17,820.3) 79.6 (19)
Follow-up 4,877.0 (1,997.2−9,014.8) 95.6 (22)
Recurrence/metastasis 15,739.3 (12,077.2−26,428.0) 21.6 (21)
 III Diagnosis 343.0 (228.5−717.0) 100 (19) 26,243.6 (17,208.5−39,075.6)
Initial treatment 15,016.7 (11,269.3−20,222.1) 100 (19)
Follow-up 4,989.8 (2,054.0−10,158.9) 95.6 (22)
Recurrence/metastasis 17,772.6 (10,892.9−24,490.1) 34.4 (21)
 IV Diagnosis 792.7 (214.6−1,339.0) 100 (19) 28,421.5 (17,869.0−50,718.4)
Initial treatment 12,882.5 (9,083.9−20,620.9) 100 (19)
Follow-up 9,239.6 (4,391.1−19,633.8) 95.6 (22)
Recurrence/metastasis 11,263.3 (8,328.8−19,025.9) 52.5 (21)