Table 1.

Optimal TBR_peak threshold values for differentiation between glioma grades, types, and molecular features, obtained with the ROC-analyses (n = 36)

Tumor characteristics	TBRpeak threshold	Sensitivity	Specificity	AUC	CI	p-value
Grade 2 (vs other gliomas)	< 2.00	0.89	0.85	0.91	0.82–1.00	< 0.001
Grade 3 (vs other gliomas)	2.00–4.521	0.25	0.89	x	x	x
Grade 4 (vs other gliomas)	> 4.52	0.94	0.84	0.89	0.76–1.00	< 0.001
Glioblastoma (vs other gliomas)	≥ 5.68	0.87	0.86	0.87	0.74–0.99	< 0.001
Oligodendroglioma (vs other gliomas)	1.45–5.682	0.44	0.81	x	x	x
Diffuse astrocytoma (vs other gliomas)	≤ 1.45	0.70	0.85	0.78	0.62–0.94	0.010
IDHwt (vs IDH1/2)	≥ 3.69	0.94	0.79	0.91	0.81–1.00	< 0.001

¹Defined from thresholds of grade 2 and grade 4 gliomas

²Defined from thresholds of diffuse astrocytomas and glioblastomas

^xNot defined, since TBR_peak thresholds for grade 3 gliomas and for oligodendrogliomas are within an interval