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. 2024 Jan 8;10:13. doi: 10.1038/s41531-024-00631-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — The receiver operating characteristic (ROC) analysis for identifying PD patients in a group consisting of both PD and non-PD subjects using (a) total substantia nigra pars compacta (SNpc) volume, (b) average SNpc contrast ratio (CR), and (c) asymmetry index. A total SNpc volume threshold of <440.6 mm³ yields an area under curve (AUC) of 0.998. An average CR threshold of <0.135 yields an AUC of 0.684. An asymmetry index threshold of >3.44 yields an AUC of 0.962.