FIGURE 4.

Expression patterns of select genes in breast epithelial cells of BRCA1 and BRCA2 mutation carriers compared with non-carriers. LHS cells (based on ESR1, FOXA1, PGR, and GATA3 expression, black circle), LASP/alveolar cells (based on KIT and ELF5 expression, blue circle; Supplementary Fig. S1 for more details), and BM cell (based on TP63, ACTG2, MYL9, and OXTR expression, orange circle) populations are indicated. Note that CXCL13 expression is absent only in BRCA1 carrier-derived cells. MIR205HG expression was observed only in epithelial cells of BRCA1 and BRCA2 mutation carriers.