Figure 3.

Cardiac Event Cumulative Incidence Curves Adjusted for Noncardiac Death

(A) Cumulative incidence of adverse cardiac events with median time to the first cardiac event following radiotherapy of 21.5 months. The 5-year cardiac event incidence was 13.8% (95% CI: 10.6%-17.0%). (B) Cardiac event incidence for left coronary arteries (TotalLeft) receiving high (V15 >2.53 cc) vs low (V15 ≤2.53 cc) radiotherapy dose, with a 5-year incidence of 26.7% vs 10.6%, respectively. (C) Adverse cardiac event incidence in high (score >5) vs low (score ≤5) CAC score to TotalLeft, with a 5-year cardiac event incidence of 28.4% vs 10.7%, respectively. (D) Cumulative risk estimates when stratifying by linear function of fixed covariate values obtained with our competing-risk regression model including age, TotalLeft CAC score >5, and TotalLeft V15. The 5-year incidence of adverse cardiac events was 6.9% for the low-risk group and 28.9% for the high-risk group. Abbreviations as in Figure 2.