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. 2023 Oct 23;8(6):101631. doi: 10.1016/j.esmoop.2023.101631
Objective To be able to perform specialist assessment, guide systemic therapy in the context of multidisciplinary treatment and counselling of patients with gestational trophoblastic neoplasia along the disease continuum
Key Concepts Describe the staging systems, including International Federation of Gynecology and Obstetrics (FIGO) anatomical staging for gestational trophoblastic neoplasia (GTN) and modified WHO prognostic scoring system
Express familiarity with the different histologic types of GTN (including complete and partial molar pregnancy, invasive mole, choriocarcinoma, placental site trophoblastic tumours and epithelioid trophoblastic tumours), including molecular pathogenesis and their prognosis
Express familiarity with the diagnostic evaluation of GTN, including the role and limitations of computed tomography, magnetic resonance imaging, and pelvic ultrasound
Recognise the role of primary surgery in the disease management
Define the management of GTN by FIGO stage and WHO scoring system including the indications for single-agent versus multiple-agent chemotherapy, and the role of chemotherapy and immunotherapy in the treatment of persistent or recurrent disease
Explain the surveillance of GTN following treatment, including the importance of (and methods for) preventing subsequent pregnancy
Skills Demonstrate the ability to:
Participate in discussion on general strategies for the management of suspected molar pregnancy
Participate in discussion on treatment of GTN (all stages), including management of placental site trophoblastic tumour and epithelioid trophoblastic tumours
Prescribe single-agent versus combination chemotherapy and to discuss the benefits and limitations of different chemotherapy options
Discuss with patients the surveillance strategy, including the prevention of subsequent pregnancy during the surveillance period and the risk of recurrent disease in a subsequent pregnancy