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. 2024 Jan 9;22:9. doi: 10.1186/s12916-023-03233-7

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© The Author(s) 2023

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Fig. 2 — Classification of BRCA1 mutation and tumor BRCA1 promoter methylation. In total, 399 patients were classified into four groups: BRCA1-non-altered (n = 127), tumor BRCA1-PM (n = 134 + 12 = 146), sBRCA1m (n = 19 + 2 = 21), and gBRCA1m (n = 94 + 11 = 105). Abbreviations: ER, estrogen receptor; PR, progesterone receptor; BRCA1-PM, BRCA1 promoter methylation; sBRCA1m, somatic BRCA1 mutation; gBRCA1m, germline BRCA1 mutation; BRCA1-non-altered, without germline BRCA1 mutation, without somatic BRCA1 mutation, and without tumor BRCA1 promoter methylation