Table 2.

Results of the mixed-effect model

	DAS28-CRP				CDAI				HAQ
	Estimate	Std. error	z value	Pr( >|z|)	Estimate	Std. error	z value	Pr( >|z|)	Estimate	Std. error	z value	Pr( >|z|)
(Intercept)	− 1.623	2.914	− 0.557	0.57761	142.9	15.8	9.048	< 0.0001	31.03	3.191	9.725	< 0.0001
year	0.000827	0.00145	0.57	0.5684	− 0.0715	0.00787	− 9.083	< 0.0001	− 0.0157	0.0016	− 9.831	< 0.0001
Age	0.00126	0.00052	2.416	0.01571	0.00616	0.00319	1.932	0.05335	0.01008	0.00087	11.538	< 0.0001
Sex	0.01499	0.01745	0.859	0.39008	0.2061	0.1073	1.921	0.05473	0.1302	0.02968	4.388	< 0.0001
Stage	0.05452	0.00498	10.943	< 0.0001	0.3038	0.0289	10.512	< 0.0001	0.06813	0.00638	10.674	< 0.0001
Class	0.09475	0.00698	13.57	< 0.0001	0.6173	0.03747	16.476	< 0.0001	0.1606	0.00738	21.768	< 0.0001
b/tsDMARDs use	− 0.0546	0.01083	− 5.041	< 0.0001	− 0.1233	0.06147	− 2.006	0.04485	0.05008	0.01282	3.908	< 0.0001
dose_MTX	0.00366	0.00121	3.036	0.0024	0.02375	0.00676	3.511	0.00045	3.6E − 05	0.00138	0.026	0.97893
dose_GC	0.00346	0.00102	3.389	0.0007	0.01246	0.0054	2.309	0.02096	0.00156	0.00099	1.579	0.11423
BMI	0.00369	0.00165	2.235	0.02544	0.00605	0.00969	0.625	0.53224	− 0.0008	0.00223	− 0.363	0.71695
RF	9.5E − 05	1.6E − 05	5.763	< 0.0001	0.00047	9E − 05	5.252	< 0.0001	5.9E − 05	1.8E − 05	3.385	0.00071
ACPA	3.3E − 05	1.2E − 05	2.782	0.0054	0.0001	6.6E − 05	1.569	0.11676	1E − 05	1.3E − 05	0.777	0.43714

DAS28-CRP Disease Activity Score 28-C-reactive protein, CDAI Clinical Disease Activity Index, HAQ Health Assessment Questionnaire Disability Index, RF rheumatoid factor, ACPA anti-citrullinated protein antibody, MTX methotrexate, GC glucocorticoid, b/tsDMARDs biologic or targeted synthetic disease-modifying antirheumatic drugs, BMI body mass index