Table 3.
Univariate analysis of risk factors for death from other diseases
| Variables | Number of patients | Incidence rate of DOD (%) | P value | |
|---|---|---|---|---|
| 5-year | 10-year | |||
| Age (years) | < 0.001 | |||
| < 70 | 529 | 2.6 | 8.2 | |
| ≥ 70 | 281 | 15.3 | 32.5 | |
| Gender | 0.233 | |||
| Male | 587 | 7.5 | 17.9 | |
| Female | 223 | 5.8 | 12.8 | |
| Performance status (ECOG) | < 0.001 | |||
| 0 | 679 | 3.8 | 10.9 | |
| 1/2/3 | 131 | 23.7 | 44.6 | |
| Body mass index (kg/m2) | 0.019 | |||
| < 22.0 | 334 | 8.7 | 21.3 | |
| ≥ 22.0 | 476 | 5.9 | 13.1 | |
| Charlson Comorbidity Index score | < 0.001 | |||
| 0 | 542 | 2.5 | 9.3 | |
| 1/2 | 232 | 13.8 | 25.8 | |
| ≥ 3 | 36 | 33.3 | 64.1 | |
| Cardiovascular disease | < 0.001 | |||
| Absent | 749 | 6.4 | 15.3 | |
| Present | 61 | 14.8 | 32.0 | |
| Respiratory disease | < 0.001 | |||
| Absent | 756 | 6.1 | 15.0 | |
| Present | 54 | 20.4 | 38.4 | |
| Renal disease | < 0.001 | |||
| Absent | 775 | 5.5 | 14.3 | |
| Present | 35 | 40.0 | 63.1 | |
| Liver disease | 0.033 | |||
| Absent | 775 | 6.5 | 15.8 | |
| Present | 35 | 20.0 | 31.7 | |
| Endocrine and collagen disease | 0.006 | |||
| Absent | 711 | 6.2 | 15.3 | |
| Present | 99 | 13.1 | 25.1 | |
| Neurological disease | < 0.001 | |||
| Absent | 759 | 6.2 | 15.2 | |
| Present | 51 | 19.6 | 37.5 | |
| Type of gastrectomy | < 0.001 | |||
| TG | 225 | 10.2 | 24.1 | |
| DG/PG/PPG | 585 | 5.8 | 13.6 | |
| Lymphadenectomy | < 0.001 | |||
| D1/1+ | 446 | 10.3 | 22.0 | |
| D2/3 | 364 | 3.0 | 10.0 | |
| Combined resection | 0.122 | |||
| Absent | 700 | 7.4 | 16.4 | |
| Present | 110 | 4.5 | 16.7 | |
| Postoperative stay in hospital (days) | 0.001 | |||
| < 20 | 450 | 5.3 | 12.3 | |
| ≥ 20 | 360 | 9.2 | 21.5 | |
| Operative time (min.) | 0.044 | |||
| < 250 | 337 | 11.0 | 21.0 | |
| ≥ 250 | 473 | 4.2 | 13.2 | |
| Blood loss (mL) | 0.813 | |||
| < 250 | 422 | 7.6 | 15.6 | |
| ≥ 250 | 388 | 6.4 | 17.1 | |
| Postoperative complications* | < 0.001 | |||
| Absent | 602 | 5.2 | 12.9 | |
| Present | 208 | 12.5 | 27.2 | |
| Pathological stage† | 0.002 | |||
| pStage I | 661 | 5.4 | 14.3 | |
| pStage II/III | 149 | 14.1 | 26.1 | |
*Grade II or higher according to the Clavien‒Dindo classification system
†Japanese classification of gastric carcinoma: 3rd English edition
DOD, death from other diseases; TG, total gastrectomy; DG, distal gastrectomy; PG, proximal gastrectomy; PPG, pylorus preserving gastrectomy