Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Jan 8;22:35. doi: 10.1186/s12967-023-04784-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 3 — Significant chromosome regions and genes affected by copy number variation (CNV) in SN-MM cell lines. (A, B) Heatmaps show the chromosome regions recurrently affected by gains or losses (A) and significant genes, previously identified as melanoma driver genes or component of PI3K/Akt/mTOR pathway, affected by CNVs (B) as detected by aCGH. The green blocks indicate copy number gain/amplification and red blocks indicate copy number loss/deletion, as labeled. (C, D) FISH analysis of the amplified regions including CCND1 amplification in SN-MM5 (C) and MYC amplification in SN-MM3 (D) parental tumor biopsies and cell-blocks. (E) Immunohistochemistry for p16^INK4a on cell blocks from SN-MM samples. Lack of p16^INK4a expression is observed in SN-MM1, SN-MM2 and SN-MM4, whereas strong reactivity is observed in SN-MM3. Sections are counterstained with haematoxylin. Magnification 200X; scale bar 100 µm