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. 2024 Jan 8;22:35. doi: 10.1186/s12967-023-04784-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Proteomic profile of SN-MM cell lines. A Heatmap showing the expression of proteins involved in the significant up-regulated biological processes (393/1148 quantified, right panel); the five proteins’ clusters are highlighted and each of them is up-regulated in a different SN-MM cell line. B Scatter plots showing the combined projections of the first three components of a principal component analysis (PCA) run considering the whole protein expression on the cell lines’ samples. C Heatmap reporting the significant Canonical Pathways differentially regulated in all SN-MM cell lines versus normal melanocytes cell line (NHEM); color intensity is inversely proportional to p-values