Figure 1.

EDCs: a promoter of diseases targeting multiple tissues. Growing evidence reveals that EDC exposures significantly impact on human health, targeting numerous tissues, including prostate, breast, liver, thyroid, adipose tissue, brain, ovary, testis, and uterus. Developmental exposures to EDCs have more negative impacts than adult exposure since organs during development are susceptible to adverse environmental exposures. EDCs can disrupt normal development patterns and alter disease susceptibility via various hormone axes and relevant pathways. Remarkably, developmental exposures to EDCs have been shown to have lifelong ramifications and even cause transgenerational effects on male and female reproduction and other diseases.