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. Author manuscript; available in PMC: 2024 Sep 28.
Published in final edited form as: J Med Chem. 2023 Sep 13;66(18):13028–13042. doi: 10.1021/acs.jmedchem.3c00982

Figure 3.

Figure 3.

Degradation activities of compounds 3b and 3e. (A) Chemical structure of 3b, 3e and 3bN. (B) MCF7 cells were treated with the compounds at 0.5 μM for indicated time. (C) and (D) MCF7 cells were treated with the compounds at the indicated concentrations for 24 h. Cell lysates were collected and the CARM1 levels were detected by western blots. The results are representative of three independent experiments. (E) and (F) DC50 and Dmax were plotted and calculated based on three independent biological triplicate western blot assays.