Table 2.

The hazard ratio and its 95 % CI and associated p-value for selected predictors derived from a Cox proportional hazards regression models for each of the three outcomes of interest. Each of the regression models control for all the covariates listed in the Methods section.

Predictor	HR (95 % CI)	p-Value	HR (95 % CI)	p-Value	HR (95 % CI)	p-Value	HR (95 % CI)	p-Value
	Time to AMI, stroke or death		Time to AMI		Time to stroke		Time to death
AF	1.10 (1.08, 1.13)	<0.0001	1.10 (1.05, 1.15)	<0.0001	1.31 (1.22, 1.39)	<0.0001	1.09 (1.06, 1.12)	<0.0001
Male	1.13 (1.11, 1.14)	<0.0001	1.12 (1.09, 1.15)	<0.0001	0.85 (0.82, 0.89)	<0.0001	1.15 (1.13, 1.17)	<0.0001
Black race (Ref = white)	1.01 (0.99, 1.04)	0.3747	1.02 (0.97, 1.06)	0.4718	1.43 (1.34, 1.52)	<0.0001	0.99 (0.97, 1.02)	0.4371
Hispanic race (Ref = white)	0.91 (0.88, 0.94)	<0.0001	0.96 (0.91, 1.01)	0.1434	1.19 (1.09, 1.29)	<0.0001	0.87 (0.84, 0.90)	<0.0001
Other/unknown race (Ref = white)	0.90 (0.87, 0.94)	<0.0001	0.98 (0.92, 1.05)	0.5677	1.18 (1.06, 1.32)	0.0031	0.87 (0.83, 0.91)	<0.0001
Age 71 to 75 (baseline = 66 to 70)	1.11 (1.08, 1.13)	<0.0001	1.06 (1.02, 1.10)	0.0035	1.11 (1.04, 1.19)	0.0030	1.15 (1.12, 1.18)	<0.0001
Age 76 to 80 (baseline = 66 to 70)	1.26 (1.23, 1.29)	<0.0001	1.09 (1.05, 1.13)	<0.0001	1.22 (1.14, 1.30)	<0.0001	1.38 (1.34, 1.41)	<0.0001
Age 81 to 85 (baseline = 66 to 70)	1.48 (1.44, 1.51)	<0.0001	1.19 (1.14, 1.24)	<0.0001	1.36 (1.28, 1.46)	<0.0001	1.67 (1.62, 1.71)	<0.0001
Age over 85 (baseline = 66 to 70)	1.90 (1.85, 1.94)	<0.0001	1.41 (1.35, 1.47)	<0.0001	1.47 (1.37, 1.58)	<0.0001	2.25 (2.19, 2.31)	<0.0001
Baseline comorbidities
Hypertension	0.95 (0.92, 0.98)	0.0036	0.98 (0.93, 1.04)	0.5708	1.13 (1.04, 1.24)	0.0060	0.91 (0.88, 0.95)	<0.0001
Diabetes mellitus	0.98 (0.96, 1.01)	0.1321	1.06 (1.01, 1.10)	0.0109	0.98 (0.92, 1.05)	0.6109	0.96 (0.93, 0.98)	<0.0001
Chronic kidney disease	1.10 (1.08, 1.12)	<0.0001	1.15 (1.10, 1.19)	<0.0001	1.03 (0.97, 1.10)	0.3436	1.10 (1.08, 1.13)	<0.0001
Stroke	1.09 (1.06, 1.11)	<0.0001	0.86 (0.82, 0.91)	<0.0001	1.58 (1.48, 1.68)	<0.0001	1.11 (1.08, 1.14)	<0.0001
Heart failure	1.27 (1.25, 1.29)	<0.0001	1.27 (1.24, 1.31)	<0.0001	1.10 (1.05, 1.15)	0.0001	1.33 (1.31, 1.36)	<0.0001
Depression	1.03 (1.00, 1.05)	0.0357	0.96 (0.91, 1.00)	0.0550	0.97 (0.90, 1.05)	0.4446	1.05 (1.02, 1.08)	0.0004
Overweight/obese	0.89 (0.86, 0.91)	<0.0001	0.92 (0.88, 0.96)	0.0004	0.90 (0.83, 0.97)	0.0064	0.86 (0.84, 0.89)	<0.0001
Sleep apnea	0.93 (0.90, 0.96)	<0.0001	0.93 (0.88, 0.99)	0.0219	1.00 (0.90, 1.10)	0.9505	0.92 (0.89, 0.96)	<0.0001
Stent placementa	1.34 (1.30, 1.38)	<0.0001	1.60 (1.52, 1.38)	<0.0001	1.11(1.03, 1.20)	0.0095	1.30 (1.26, 1.35)	<0.0001
CABGa	0.56 (0.55, 0.58)	<0.0001	0.49 (0.47, 0.52)	<0.0001	0.77 (0.71, 0.82)	<0.0001	0.55 (0.53, 0.57)	<0.0001
			Medications
Beta blockers	1.00 (0.98, 1.01)	0.6085	1.09 (1.06, 1.12)	<0.0001	1.08 (1.03, 1.12)	0.0008	0.96 (0.95, 0.98)	<0.0001
ACE inhibitors	0.98 (0.97, 1.00)	0.0132	1.03 (1.00, 1.05)	0.0453	0.99 (0.95, 1.04)	0.7697	0.97 (0.95, 0.98)	<0.0001
ARB	0.91 (0.89, 0.92)	<0.0001	0.97 (0.94, 1.00)	0.0830	1.02 (0.97, 1.07)	0.5560	0.88 (0.86, 0.89)	<0.0001
Clopidogrel	1.06 (1.05, 1.08)	<0.0001	1.19 (1.16, 1.23)	<0.0001	1.17 (1.11, 1.23)	<0.0001	1.03 (1.01, 1.05)	0.0029
Warfarinb	0.84 (0.82, 0.85)	<0.0001	0.90 (0.86, 0.93)	<0.0001	1.07 (1.00, 1.14)	0.0409	0.79 (0.77, 0.81)	<0.0001

^aProcedure during index admission.

^bPresent 90 days after index; HR, hazard ratio; CI, confidence interval; ACEi, angiotensin converting enzyme inhibitor; ARB, angiotensin receptor blocker.