Table 3.
Predicted activators of MTF-1 identified using the biomarker and examined for further study
| Predicted MTF-1 activator | Description | Cell line(s) | Treatment s) (h) | Treatment concentration(s) (μM) |
Data source |
|---|---|---|---|---|---|
|
| |||||
| Mefloquine | Antimalarial | PC3, MCF7, HL60 | 6 | 9.6 | GSE5258 |
| Alexidine | Antimicrobial | PC3, MCF7, HL60 | 6 | 6.8 | GSE5258 |
| Phenoxybenzamine | Alpha blocker | PC3, MCF7 | 6 | 11.8 | GSE5258 |
| Astemizole | Antihistamine | PC3, MCF7, HL60 | 6 | 8.8 | GSE5258 |
| Disulfiram | Alcohol aversion drug | PC3, MCF7, HL60, hepatocytes | 6, 8 | 13.4, 60 | GSE5258, TG-GATES |
| Clioquinol | Antifungal | PC3, MCF7, HL60 | 6 | 13 | GSE5258 |
| Suloctidil | Vasodilator | PC3, MCF7, HL60 | 6 | 11.8 | GSE5258 |
| Thiostrepton | Antibiotic | PC3, MCF7 | 6 | 2.4, 10 | GSE40766, GSE5258 |
| Deoxycholic acid | Bile acid | SKGT4, HET1A | 4, 8, 12, 24 | 100, 300 | GSE13400 |