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. Author manuscript; available in PMC: 2024 Jan 27.
Published in final edited form as: J Leukoc Biol. 2023 Jul 27;114(2):142–153. doi: 10.1093/jleuko/qiad045

Fig. 3.

Fig. 3.

Pairwise comparison of the inflammatory mediators in HIV+/PWID−, HIV−/PWID+, and HIV+/PWID+. Bridge normalized NPX values from Olink Target 96 Inflammation Panel were used to compare levels of 74 inflammatory mediators between HIV−/PWID− (controls; CON), HIV+/PWID− (HIV), HIV−/PWID+ (IDU), and HIV+/PWID+ (DP) A) post-adjusting for age, homeless in the past year or now, male identity, married, employed, and some college experience (ANCOVA). B) The adjusted data were also subjected to 2-way ANOVA to identify HIV infection, injection drug use, and interaction (synergy) effects. C) GO enrichment analysis was performed for the inflammatory mediators with significant interaction effects in B, and the most specific subclass of the hierarchical ontology cluster is shown. The estimate difference (adjusted mean difference) (A), coefficient estimates (effect size) (B), and −log(false discovery rate) (C) are shown when significant (P < 0.05).