Skip to main content
. Author manuscript; available in PMC: 2024 Oct 1.
Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2023 May 30;1869(7):166769. doi: 10.1016/j.bbadis.2023.166769

Fig. 1.

Fig. 1.

Mechanism of action of dichloroacetate (DCA). PDK phosphorylates and inhibits the activity of PDH while PDP dephosphorylates and activates PDH. Under hypoxic conditions activation of PDK results in phosphorylation and inactivation of PDH and reduced conversion of pyruvate to acetyl CoA. DCA inactivates PDK resulting in the activation of PDH.