Table 2.
Representative functional clusters of canvaxgens (i.e. cancer vaccine antigen genes) using DAVID
| Functional cluster | Enrichment score | No. of canvaxgens | FDR | No. of terms in cluster |
|---|---|---|---|---|
| Signal | 15.99 | 102 | 1.1E−20 | 4 |
| Glycoprotein | 106 | 7.1E−13 | ||
| Cytokine activity | 8.51 | 5 | 2.87E−7 | 5 |
| Plasma membrane | 7.57 | 100 | 2.3E−13 | 11 |
| Host cell receptor for virus entry | 5.03 | 9 | 3.8E−4 | 4 |
| Host–virus interaction | 22 | 6.8E−4 | ||
| Toll-like receptor signaling pathway | 4.68 | 12 | 3.8E−7 | 3 |
| Positive regulation of MAP kinase activity | 4.36 | 10 | 4.3E−8 | 3 |
| Tumor antigen | 3.88 | 8 | 9.6E−6 | 7 |
| Pathways of cancer | 2.64 | 30 | 3.7E−8 | 121 |
The first seven enriched functional clusters listed are the top 7 clusters based on enrichment score calculated by the DAVID tool, and the ‘pathways of cancer’ cluster is the 14th most significant out of 21.