Table 2.

Duration of neutropenia in TAC chemotherapy cycle 1

	Efbemalenograstim alfa		Pegfilgrastim 6 mg N = 30
	240 µg/kg N = 30	320 µg/kg N = 29
Moderate and severe neutropenia (ANC < 1.0 × 109/L)
Duration, days
Mean (SD)	2.1 (1.58)	2.1 (1.46)	1.8 (1.28)
Median (range)	2.0 (0, 6)	2.0 (0, 4)	2.0 (0, 4)
Difference vs. pegfilgrastim (95% CI)	0.3 (−0.4, 1.1)	0.3 (−0.4, 1.1)
Non-inferior to pegfilgrastim?	Yes	Yes
Superior to pegfilgrastim?	No	No
Severe neutropenia (ANC < 0.5 × 109/L)
Duration, days
Mean (SD)	1.5 (1.55)	1.4 (1.15)	1.1 (1.01)
Median (range)	1.0 (0, 6)	2.0 (0, 4)	1.0 (0, 3)
Difference vs. pegfilgrastim (95% CI)	0.4 (−0.2, 1.0)	0.4 (−0.3, 1.0)

ANC Absolute neutrophil count; CI Confidence interval; SD Standard deviation; TAC Taxotere® [docetaxel] + doxorubicin + cyclophosphamide