Table 1.
Baseline demographics and disease characteristics
| Treatment-naïve (n = 1478) | Previously treated (n = 384) | |
|---|---|---|
| Patient demographics | ||
| Age, years | 61.9 ± 10.5 | 62.9 ± 9.3 |
| Female, n (%) | 723 (48.9) | 222 (57.8) |
| Race, n (%)a | ||
| Asian | 515 (40.8) | 35 (9.1) |
| Black | 8 (0.6) | 0 |
| White | 736 (58.4) | 346 (90.3) |
| Multiple | 2 (0.2) | 2 (0.5) |
| Missing, nb | 217 | 1 |
| Time from DME diagnosis to first IVT-AFL treatment, months | ||
| Meanc | 9.0 ± 29.8 | 24.8 ± 31.5 |
| Median | 0.9 | 15.7 |
| Visual characteristics | ||
| VA, letters | 56.0 ± 19.8 | 50.8 ± 19.5 |
| Missing, n | 67 | 6 |
| VA categories, n (%)a | ||
| < 35 letters | 163 (11.6) | 54 (14.3) |
| 35–69 letters | 791 (56.1) | 244 (64.6) |
| ≥ 70 letters | 457 (32.4) | 80 (21.2) |
| Anatomic characteristics | ||
| CRT, µm | 437 ± 140 | 465 ± 148 |
| Missing, n | 186 | 24 |
| SRF present, n (%)a | 340/1011 (33.6) | 106/299 (35.5) |
| Missing, n | 467 | 85 |
| IRF present, n (%)a | 939/1019 (92.1) | 287/299 (96.0) |
| Missing, n | 459 | 85 |
Data are mean ± standard deviation unless otherwise stated
CRT, central retinal thickness; DME, diabetic macular edema; IRF, intraretinal fluid; IVT-AFL, intravitreal aflibercept; SRF, subretinal fluid; VA, visual acuity
aProportions calculated based on the number of patients with data available at baseline
bFrance does not allow the collection of race data in clinical studies
cThe median is considered to be a more accurate reflection of the time from DME diagnosis to first IVT-AFL treatment, due to the effect of outliers on the mean value