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. 2024 Jan 9;15(1):18. doi: 10.1038/s41419-023-06299-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Drawing of 3D device filled with cell-loaded hydrogel spheroids. Device allows continuous perfusion of nutrients and treatment conditions to spheroids, with simultaneous collection of secretions and metabolites. In addition, cells can be recollected after culture for downstream analysis. B Diagram depicting some of the biological characteristics observed in NK cells and DBLCL cultured in our spheroid platform. C, D Representation of images taken from spheroid devices. C Enlarged drawing of array loaded with hydrogel spheroids containing cell. D, E In all, 20× magnified images of spheroids containing DLBCL and NK cells. D Before rCHOP treatment and E) After rCHOP treatment. DLBCL are labeled in blue, NK cells are labeled in green, and ethidium homodimer labels dead cells with red fluorescence.