Table 1.

Reduced gray-matter volume in physio-cognitive decline syndrome subjects of two aged groups

	Anatomical region		MNI-space coordinates			Maximum intracluster t value
Cluster size	Side	Structure	X	Y	Z
Reduced GMV in PCDS < 65 years old
598	Left	Occipital pole	−13.5	−100.5	0	3.99
405	Left	Precentral gyrus	−58.5	7.5	15.0	4.32
298	Right	Amygdala	25.5	0	−27.0	3.69
255	Left	Cerebellum V	−18.0	−45.0	−16.5	3.40
138	Left	Cerebellum VIIIa	−24.8	−62.3	−47.3	4.38
Reduced GMV in PCDS ≥ 65 years old
30986	Right	Hippocampus	32.3	−15.8	−10.5	6.97
	Right	Thalamus	1.5	−12.0	−10.5	6.51
	Left	Amygdala	−27.0	−12.0	−15.0	6.19
2580	Right	Cerebellum Crus I	30.8	−66.0	−33.0	4.29
2013	Left	Cerebellum Crus I	−31.5	−69.0	−31.5	4.37
1274	Right	Occipital pole	13.5	−91.5	30.0	4.68
869		Cerebellum vermis VIIIa	4.5	−67.5	−39.0	3.99
598	Right		58.0	−25.5	16.0	4.14
584	Right	Postcentral gyrus	45.0	−19.5	63.0	3.90
562	Right	Lateral occipital cortex	52.5	−63.0	13.5	4.32
545	Right	Cingulate gyrus	7.5	1.5	40.5	4.23

Analyses adjusted for age, sex, Centre for Epidemiologic Studies Depression Scale and cardiovascular risk factors (hypertension, diabetes, hypderlipidemia, smoking and obesity). MNI = Montreal Neurological Institute. GMV = gray-matter volume.