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. 2024 Jan 9;16(1):e12504. doi: 10.1002/dad2.12504

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© 2024 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Correlation of NfL at baseline with PRS‐CS in the AD at 90 months and the control group. The association of NfL at baseline (z‐scores) and PRS‐CS (z‐scores) is depicted for all participants (A), participants with AD diagnosis at 90 months (B), and the control group (C). There is a significant difference in Spearman's correlation coefficient (r) between the AD at 90 months and the control group (AD r = 0.75, controls r = −0.06, p < 0.001). Correlations are visualized by least‐squares regression line. AD, Alzheimer's disease; NfL, neurofilament light chain; PRS‐CS, polygenic risk score continuous shrinkage.