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. 2023 Dec 20;99:104922. doi: 10.1016/j.ebiom.2023.104922

Fig. 3.

Fig. 3

Anti-DENV1-4 IgG response∗ to PepGNP-Dengue vaccination. Kinetics of anti-NS1 (a and c) and anti-DENV1-4 particles (b and d) IgG levels are shown in groups vehicle-GNP (n = 6), LD PepGNP-Dengue (n = 10) and HD PepGNP-Dengue (n = 10). In (a and b), antibody titres (RU/ml) above the grey zone are positive (>22 RU/ml). In (c and d), fold change from baseline; bars indicate medians and 95% confidence intervals. Intra-group comparisons with day 0 used non-parametric Friedman tests; inter-group comparisons used non-parametric Kruskal–Wallis tests at each timepoint. p values <0.05 are indicated. Pink symbols indicate participants with TBE positive response. ∗Measured by enzyme-linked immunosorbent assay. LD = low dose (○); HD = high dose (▵); GNP = gold nanoparticles; TBE = tick-borne encephalitis.